1 Paracrine and Endocrine Modes of Myostatin Action 1 2 3 4

نویسندگان

  • Yun-Sil Lee
  • Thanh V. Huynh
  • Se-Jin Lee
چکیده

Paracrine and Endocrine Modes of Myostatin Action 1 2 3 4 Yun-Sil Lee, Thanh V. Huynh, and Se-Jin Lee* 5 6 Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 7 725 North Wolfe Street, PCTB 803, Baltimore, MD 21205, USA 8 9 *Correspondence: Se-Jin Lee 10 Johns Hopkins University School of Medicine, Molecular Biology and Genetics, PCTB 803 11 725 North Wolfe Street, Baltimore, Maryland 21205, USA 12 Tel: (410) 614-0198 13 FAX: (410) 614-7079 14 Email: [email protected] 15 16 Articles in PresS. J Appl Physiol (January 14, 2016). doi:10.1152/japplphysiol.00874.2015

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Paracrine and endocrine modes of myostatin action

Myostatin (MSTN) is a secreted signaling molecule that normally acts to limit muscle mass. In adult animals, MSTN is made almost exclusively by skeletal muscle and circulates in the blood. A critical question is whether this circulating MSTN protein can enter the active pool to regulate muscle growth or whether all of the activity of MSTN results from locally produced protein. Here, we addresse...

متن کامل

Seasonal variation of myostatin gene expression in pectoralis muscle of house sparrows (Passer domesticus) is consistent with a role in regulating thermogenic capacity and cold tolerance.

Winter acclimatization in small birds overwintering in cold climates, including house sparrows (Passer domesticus), is associated with improved cold tolerance, elevated summit metabolic rates (M(sum) = maximum cold-induced metabolic rate), and increased pectoralis muscle mass compared to summer birds. Myostatin is a potent autocrine/paracrine inhibitor of skeletal muscle growth in mammals and b...

متن کامل

The Sertoli cell: Novel clinical potentiality.

The Sertoli cell is important for endocrine and paracrine control of spermatogenesis. Functions attributed to Sertoli cells are: (1) supportive and trophic functions for the cells of the seminiferous epithelium, (2) transport of mature spermatids towards the lumen of seminiferous tubules, (3) secretion of androgen binding protein, (4) production of substances with endocrine or paracrine action ...

متن کامل

Adipose Tissue-Derived Stem Cell Secreted IGF-1 Protects Myoblasts from the Negative Effect of Myostatin

Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Muscular Dystrophy (DMD). But the protective effect of stem cell secreted IGF-1 ...

متن کامل

Localized expression of aromatase in human vascular tissues.

The atheroprotective effects of estrogen are well established and the presence of an estrogen receptor in vascular tissues has recently been reported. Therefore, we investigated the localization of the estrogen-producing enzyme aromatase in vascular tissues to assess the possible contribution of endocrine, paracrine, and autocrine modes of action. Aromatase was found in human vascular smooth mu...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015